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The radiobiology was characterized by in vivo irradiation of rat liver, dog liver, and dog brain. The low morbidity of this procedure and its efficacy in patients with refractory pain related to rsd suggest that scs is superior to ablative sympathectomy in the management of rsd. All 12 patients experienced relief of pain after trial stimulation and had their systems permanently implanted.

The purpose of the present study was to investigate whether meningeal fibrosis causes increased resistance to cerebrospinal fluid outflow (r(out)) andor increased b-wave activity and whether pathological changes in the brain parenchyma after brain compliance, causing increased b-wave activity. Scs is an effective treatment for the pain of rsd, including recurrent pain after ablative sympathectomy. The purpose of this study was to determine the efficacy of spinal cord stimulation (scs) in patients with symptoms of reflex sympathetic dystrophy (rsd), a disabling clinical condition with significant consequences of morbidity and loss of productivity.

Rats and dogs that were killed weeks to months after liver irradiation tended to have sharply demarcated lesions. Furthermore, possible correlations between white matter lesion scores, ventricular width, and age were investigated. Liver enzyme levels, measured serially in the dogs, did not give evidence of chronic inflammation.

At an average of 41 months follow-up, all patients were using their stimulators regularly and only two were receiving adjunctive minor pain medication. An analysis of our records revealed 12 consecutive patients diagnosed as having rsd before undergoing scs. The study involved a group of 38 consecutively studied patients with clinical and radiological evidence of idiopathic nph, for whom a frontal brain biopsy was obtained.

The device is lightweight, handheld, and battery-powered, and it emits x-ray radiation from the tip of a probe 3 mm in diameter by 10 cm in length. Histological examination of the brains of dogs that were killed acutely after irradiation did not show evidence of inflammation, edema, or hemorrhage. The level of pain present pre- and postoperatively was determined by administering a modified mcgill pain questionnaire and a visual analog scale to each patient.

For 29 patients, hydrodynamic criteria of nph were fulfilled and a ventriculoperitoneal shunt was performed. . We report the design and initial characterization of the dosimetry and radiobiology of a novel device for interstitial stereotactic radiosurgery. Meningeal fibrosis andor obliteration of the subarachnoid space has been suggested as the pathoanatomic basis. Heat transfer from the probe to dog brain was studied in vivo by placing thermocouple sensors around the probe tip before irradiating.


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    The results suggest that leptomeningeal fibrosis is not the only pathoanatomic basis of increased r(out) andor b-wave activity in patients with nph and that various degenerative changes in the parenchyma may be responsible for the altered cerebrospinal fluid dynamics characteristic of nph. Histological examination of the brains of dogs that were killed acutely after irradiation did not show evidence of inflammation, edema, or hemorrhage. Heat transfer from the probe to dog brain was studied in vivo by placing thermocouple sensors around the probe tip before irradiating. Liver enzyme levels, measured serially in the dogs, did not give evidence of chronic inflammation. Rats and dogs that were killed weeks to months after liver irradiation tended to have sharply demarcated lesions.

    Meningeal fibrosis andor obliteration of the subarachnoid space has been suggested as the pathoanatomic basis. For 29 patients, hydrodynamic criteria of nph were fulfilled and a ventriculoperitoneal shunt was performed. The low morbidity of this procedure and its efficacy in patients with refractory pain related to rsd suggest that scs is superior to ablative sympathectomy in the management of rsd. At an average of 41 months follow-up, all patients were using their stimulators regularly and only two were receiving adjunctive minor pain medication. Both dosimetric methods showed a steep dose-distance fall-off relationship (proportional to the reciprocal of the cube of the distance from the probe tip).

    The radiobiology was characterized by in vivo irradiation of rat liver, dog liver, and dog brain. The purpose of the present study was to investigate whether meningeal fibrosis causes increased resistance to cerebrospinal fluid outflow (r(out)) andor increased b-wave activity and whether pathological changes in the brain parenchyma after brain compliance, causing increased b-wave activity. Scs is an effective treatment for the pain of rsd, including recurrent pain after ablative sympathectomy. An analysis of our records revealed 12 consecutive patients diagnosed as having rsd before undergoing scs. . The purpose of this study was to determine the efficacy of spinal cord stimulation (scs) in patients with symptoms of reflex sympathetic dystrophy (rsd), a disabling clinical condition with significant consequences of morbidity and loss of productivity. The device is lightweight, handheld, and battery-powered, and it emits x-ray radiation from the tip of a probe 3 mm in diameter by 10 cm in length. The animals were killed at varying intervals of time, and histological examinations were performed. We report the design and initial characterization of the dosimetry and radiobiology of a novel device for interstitial stereotactic radiosurgery. The study involved a group of 38 consecutively studied patients with clinical and radiological evidence of idiopathic nph, for whom a frontal brain biopsy was obtained.

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